Regenerative and Aesthetic Medicine and Dentistry (PRF)

Regenerative and Aesthetic Medicine and Dentistry (PRF Methods)

Regenerative and Aesthetic Medicine and Dentistry (PRF)

Regenerative and Aesthetic Medicine and Dentistry (PRF)

We have years of experience using PRF (platelet-rich fibrin) in oral surgery, periodontology, and aesthetic medicine.

Regenerative and Aesthetic Medicine and Dentistry (PRF)

We have years of experience using PRF (platelet-rich fibrin) in oral surgery, periodontology, and aesthetic medicine.

PRF utilizes the potential of our blood cells to naturally enhance wound healing and bone regeneration in oral surgery.

We also use PRF in periodontology, where this method can improve the aesthetics and health of the supportive structures of the tooth (periodontium).

A major potential of PRF lies in aesthetic medicine where it is used in various rejuvenation procedures. It is the only method that does not involve any pharmaceutical preparations during application, using only the patient’s own blood, making it completely natural. PRF, as a rejuvenation method for skin, is becoming increasingly popular.


Women are increasingly avoiding treatments that deform the natural appearance of their face over time. Let's not neglect the male population either.

Treatments using the patient’s own blood have advanced in recent years alongside the development of regenerative medicine. PRF (Platelet-Rich Fibrin) is the most advanced method and, unlike the more well-known PRP (Platelet-Rich Plasma), has a significantly stronger effect. This is because the biomaterial is prepared using much gentler forces and without any additives, making the blood-derived product much more potent, effective, and entirely natural.

PRF can also be used in a thinner form (i-PRF+) that contains more blood cells and a "thicker" form (liquid A-PRF) that contains more fibrin, making it usable as a natural filler. The fibrin network releases growth factors over a longer period, stimulating collagen production and providing longer-lasting effects.

Of course, all the effects are not immediately visible, as with Botox or fillers, but they are natural, “long-term,” and, importantly, have no harmful effects or potential complications.

It is also possible to combine PRF and liquid A-PRF, a technique known as the Cleopatra technique (Nacopoluos C, Vesala AM. Lower facial regeneration with a combination of platelet-rich fibrin liquid matrices based on the low-speed centrifugation concept – Cleopatra technique. J Cosmet Dermatol. 2019; 00:1-5.), which Dr. Kovačević learned from the author herself at her clinic in Athens.

The biomaterial can be used with microneedling and as injections (mesotherapy), or in combination. For mesotherapy, we can also use the most advanced biorevitalization cocktails, depending on the client's preference. It is also applied in the treatment of alopecia (hair loss), scar treatments, etc.

What is PRF?

PRF (platelet-rich fibrin) is a natural method that uses the patient’s blood for wound healing, bone regeneration, and skin rejuvenation, without chemicals or pharmaceutical preparations.

How does PRF rejuvenate the skin?

PRF stimulates collagen production, refreshes the face, and slows down aging without the risk of deformation. It is used in microneedling, injections, and hair loss therapies.

What is the difference between PRF and PRP?

PRF is more effective and natural than PRP because it is prepared without additives and using gentler forces, which allows for a stronger regenerative effect and longer-lasting results.

What is PRF?

PRF (platelet-rich fibrin) is a natural method that uses the patient’s blood for wound healing, bone regeneration, and skin rejuvenation, without chemicals or pharmaceutical preparations.

How does PRF rejuvenate the skin?

PRF stimulates collagen production, refreshes the face, and slows down aging without the risk of deformation. It is used in microneedling, injections, and hair loss therapies.

What is the difference between PRF and PRP?

PRF is more effective and natural than PRP because it is prepared without additives and using gentler forces, which allows for a stronger regenerative effect and longer-lasting results.

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Ordinacija dentalne medicine
dr. sc. Maja Kovačević dr. med. dent.

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